If you're sending the email out to a small number of people (under 50), then it shouldn't be a problem.If you're sending it to a large crowd, then you should be a distribution application or service.
The number of recipients for outbound emails are limited to 50, so it is not typically used as criteria in determining that an email is spam.
Our email servers are using spam evaluation process that is set to the most lenient levels.
This means it is difficult for your emails to be tagged as spam and prevented from going out unless they have a lot of features of a spam message.
Spam is a constant threat that comprises almost 80% of all email sent on the planet.
In an effort to do our part and protect both our servers and customers, we have recently implemented outbound spam filtering.